the C9ORF72 mutation which is also involved in frontotemporal dementia and these have also uncovered some characteristic phenotypes in ALS (Donnelly et al., 2013; Sareen et al., 2013; Hedges et al., 2016). All this further supports the notion of iPSCs' culture studies as models unraveling a lot that needs to be known about neurodegenerative disease such as ALS that we know about the very little.
