Exploratory and confirmatory analyses of phenotypic data revealed a single latent variable (AUD factor; see Table 3). All items loaded on the single latent factor >0.84. Excellent model fit (RMSEA < 0.05, CFI/TLI > 0.95) supports the CPM that describes the phenotypic relationships between symptoms as arising from an unobserved latent trait. Common SNPs explained 36% (standard error [SE] = 0.13, p = 0.002) of the variation in the AUD factor score.
