Common SNPs explained 14% (standard error [SE] = 0.21, p = 0.24 of the variation in DSM-5 AUD diagnosis and 22% (SE = 0.13, p = 0.04) of the variation in AUD severity (i.e., ln-transformed DSM-5 AUD categories). Across the 11 AUD symptoms, SNP-heritability estimates varied from 13% (Great time spent using/recovering) to 39% (Using longer than intended), with five of the 11 items reaching significance (p < 0.05) and four items reaching nominal significance (p < 0.10) (see Table 2).
