Concordant with the emergence of oxidative stress by PWSI, the time spent in unprotected open arms of the PWSI KO mice in the elevated plus maze was significantly reduced compared to that of fGluN1 controls, an impairment absent in group-housed KO mice of the same age (Figure 2B). Chronic APO treatment alleviated this PWSI-induced anxiety-like behavior in the KO mice (Figure 2B).
