Behavioral tasks were conducted after chronic treatment with APO (Figure 2A) to investigate whether a reduction in PWSI-induced oxidative stress was associated with behavioral improvement. APO treatment significantly improved performance on tests of anxiety (Figure 2B), spatial memory (Figure 2D), prepulse inhibition (Figure 2E), saccharine preference (Figure 2G), and nest building (Figure 2F), while having no effect on overall activity (Figure 2C) or startle responses (Figure 2F). Considering the actions of APO, these findings suggest that PWSI mediates its effects on behavior by enhancing oxidative stress.
