Chunk #9 — Results — Post-weaning social isolation (PWSI) augmented cortical ROS levels in KO mice

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Social isolation exacerbates schizophrenia-like phenotypes via oxidative stress in cortical interneurons.

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Next we tested whether apocynin (APO), an antioxidant and ROS scavenger, alleviated the elevation of cortical ROS levels in KO mice after PWSI. Animals were treated with APO from P14 and subjected to PWSI from P21 (Figure 2A). Cortical ROS levels in PWSI KO mice were largely abolished by chronic APO treatment (Figures 1C & D, decrease to 35.4 ± 11.1% in mPFC and decrease to 28.7 ± 5.0% in S1 cortex).