for the primary CD symptom count analysis. Four SNPs reached genome-wide significance with CD symptom count, based on P < 5 × 10−8. Two of these SNPs (rs16891867 and rs1861046) were in the gene C1QTNF7 (C1q and tumor necrosis factor-related protein 7). These SNPs were in high LD (r2= 0.97). There were 40 SNPs tested across this gene in the GWAS panel; 6 additional SNPs in the gene yielded P < 0.05. The average r2 between these SNPs and rs16891867 and rs1861046 was 0.24 (range 0.09–0.76), indicating that they provide some independent, converging evidence of association in the gene. The other top two SNPs meeting genome-wide significance were intergenic and located on chromosomes 11 and 13.
