Bierut et al. (2010) performed a GWAS of AD in the Study of Addiction: Genetics and Environment (SAGE) sample, tested over 900,000 SNPs in 1,235 European-American (EA) and 662 African-American (AA) cases and 1,433 EA and 499 AA alcohol-exposed controls. Although, in the combined EA/AA sample, 15 SNPs were identified with P < 10−5, the findings were not replicated in two independent datasets. There was modest evidence to replicate a SNP identified by Treutlein et al. (rs13160562 in ERAP1, P=0.03), but no other findings from that GWAS were replicated.
