Edenberg et al. (2010) performed a GWAS using over 800,000 SNPs in a family-based sample of 847 AD EA cases and 552 EA controls and 345 AA cases and 140 AA controls from the Collaborative Study on the Genetics of Alcoholism (COGA) sample, which included 612 EA AD cases and 413 EA controls previously analyzed in Bierut et al. (2010). Their primary analysis was a case-control study in the EA sample. They also repeated the analyses restricting the cases to those meeting early onset-AD and extended the analysis to the AA sample. They found no GWS associations in any of the analyses, and although the EA sample overlapped substantially with that of Bierut et al. (2010), results from the two studies differed substantially.
