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Chunk #10 — Findings from classical AD GWAS

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Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
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Kendler et al. (2011) performed an AD GWAS in a population-based sample of 2,357 EAs and 812 AAs from the Molecular Genetics of Schizophrenia (MGS2) control sample. Rather than examining association with case-control status, this study examined a quantitative AD criterion factor score. Although no GWS SNPs were identified in either sample, three genes (PITRM1, PIGG, and AKAP9) were significant in the gene-based analysis in EAs.