Chunk #23 — Results — Associations of CNR1 with CD in the EA family sample

Source

Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

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the effects of AD, OD, MD and R-SD, the association signal remained significant for SNP8 (PCDnoAD=0.012; PCDnoOD=0.021; PCDnoMD=0.014; PCDnoR-SD=0.020). After excluding ND, the association signal for CDnoND decreased; a “trend-level possible” association signal remained (P=0.071). At SNP3, the “trend-level possible” association signals (P=0.060) remained or became significant after excluding the effect of AD (PCDnoAD=0.036), OD (PCDnoOD=0.036), ND (PCDnoND = 0.072), MD (PCDnoMD=0.068) or R-SD (PCDnoR-SD=0.062).