For CIP, nominally significant association signals were observed at two SNP8-linked loci, i.e., rs1049353 (SNP7) (P=0.015) and rs2146274 (SNP10) (P=0.010). SNP3 and SNP8 were not significantly associated with CIP (PSNP3=0.081, and PSNP8 = 0.071). In the global haplotype association test, the SNP8-containing haplotype showed a highly significant association with CIP (P=0.003), which remained significant after correcting for multiple testing (with α=0.017). These findings suggest that the SNP8 locus may also be important in CIP. However, we failed to observe an interaction effect between SNP3^G+ and SNP8^T/T on CIP.
