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Chunk #8 — Online Methods — Patient and population cohorts — NFBC1966

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A new highly penetrant form of obesity due to deletions on chromosome 16p11.2.
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The Northern Finland Birth Cohort 1966 is a prospective birth cohort of almost all individuals born in 1966 in the two northernmost provinces of Finland. Expectant mothers were enrolled and clinical data collection took place prenatally, at birth, and at ages six months, one year, 14 years and 31 years. Biochemical and DNA samples were collected with informed consent at age 31 years. Genotyping using the Illumina Infinium 370cnvDuo array and phenotypic characteristics of the cohort were as previously described17. Phenotypic and genotyping data was available for 5246 subjects after quality control.