Targeted FOXP2 downstream target gene sets were analysed for association with ADHD. Three sets were examined: 1) Putative target genes of Foxp2 that were enriched in wild type compared to control Foxp2 knockout mouse brains in ChIP-chip experiments (219 genes), 2) Genes showing differential expression in wild type compared to Foxp2 knockout mouse brains (243 genes), and 3) FOXP2 target genes that were enriched in either or both basal ganglia (BG) and inferior frontal cortex (IFC) from human fetal brain samples in ChIP-chip experiments (258 genes). Curated short lists of high-confidence genes were obtained from Vernes et al.89 and Spiteri et al90.
