Ethanol consumption and acute ethanol withdrawal in HS4, generation 19, mice. For acute withdrawal, animals were first tested at T−30 min and T−10 min for baseline withdrawal scores. At T−0, animals were injected with 4 g/kg of ethanol. Testing for HICs began at T+2 h and continued for every hour up to 12 h. Animals were always phenotyped for consumption first. a The relationship between consumption and withdrawal for individual mice (N=348). b The relationship when the data are collapsed across families (N=48). Consumption is expressed as grams of ethanol consumed per 24 h. Withdrawal is expressed as the CAUC for HICs. To calculate the CAUC, the average baseline score was subtracted from the postethanol scores
