Overall, the current study illustrates that STSB from HS4 animals resulted in the detection of reciprocal QTLs for acute ethanol withdrawal and ethanol consumption. The coincident and reciprocal QTLs detected in the current study appear to be different from those previously described (Metten et al. 1998a). Finally, the advantage of mapping in HS4-selected animals is illustrated: The proximal Chr 1 QTL was readily refined in terms of interval size and in terms of generating plausible candidate genes.
