Finally, we examined the ARC/NMDAR gene sets in the large case–control data sets. In this completely independent analysis, case CNVs were significantly enriched for members of the NMDAR (P=0.0015) but not ARC complexes (P=0.14). We note that in the de novo analysis, much of the additional signal for the ARC complex (over and above that of the NMDAR) comes from CNVs at 15q11.2 that span CYFIP1. Although there is strong published evidence for deletions at this locus being relevant to schizophrenia,3, 7 this locus was not significantly enriched in the MGS study,4 and was excluded by the filtering criteria adopted by the ISC,2 the two studies that combined comprise a large proportion of the case–control data set we use in this study.
