To exclude the possibility that our results reflect general properties of de novo CNVs, we compared case de novo CNVs with de novo CNVs identified in the control individuals from Iceland and from the Autism study by Sanders et al.25 Despite fewer control CNVs in these samples (N=59 and N=14), and therefore reduced power, the findings were consistent with our primary analysis in showing significant enrichment of ARC and NMDAR (Table 2) as were those of sensitivity analysis restricted to very large CNVs (>500 kb) (ARC P=1.27 × 10−4; NMDAR P=1.72 × 10−2).
