To exclude unknown possible sources of confounding arising from the use of control CNVs, we also compared gene sets hit by de novo CNVs from cases with those hit in random assignments of gene-hitting CNVs of the same size, ensuring the probability of a gene being hit was proportional to its size. Again, we observed significant enrichment of PSD genes (P=0.0024), and a highly significant enrichment of the ARC (2.21 × 10−8) and NMDAR (2.95 × 10−4) complexes (Supplementary Section 12).
