In the Yale-Penn participants of African descent, we observed the HGF gene survived Bonferroni multiple testing correction for the StructLMM interaction test (p = 1.08 × 10−6) and approached significance in the association test (p = 3.39 × 10−6). Within the HGF gene region, we did not observe a driving single-variant association/interaction (all p > 10−5). Although the phenome-wide scan did not show any association surviving multiple testing correction (p = 1.05 × 10−5), the strongest HGF association was with one of the traumatic events assessed in the UK Biobank35, Data-Field 20526: “Been in serious accident believed to be life-threatening” (p = 1.21 × 10−5).
