To follow up the consistent genetic overlap identified previously4–8, we focused our attention on MD PRS from a large-scale MD GWAS conducted by PGC investigators33. In the Yale-Penn cohort, the MD PRS was positively associated with suicidality (Supplemental Table 7): persistent SI (Yale-Penn OR = 1.26, 95% CI = 1.09–1.46, FDR q = 0.011), SP (Yale-Penn OR = 1.28, 95% CI = 1.13–1.47, FDR q = 0.005), and SA (Yale-Penn OR = 1.26, 95% CI = 1.09–1.45, FDR q = 0.011). However, there was no interaction between MD PRS and SD-related traits with respect to suicidality phenotypes (Supplemental Table 8).
