For SNP-2 we found that, compared to subjects homozygous for the C allele, T carriers had significantly reduced concentration in the left hippocampus (Talairach coordinates for the maximal point of difference: x=−22mm, y=−33mm, z=−4mm, T=3.28, P=0.001 uncorrected, 35 voxels) (Figure 1a). For SNP-3, compared to the subjects homozygous for the C allele, A carriers had significantly reduced concentration in the left hippocampus (Talairach coordinates for the maximal point of difference: x=−20mm, y=−31mm, z=−5mm, T=3.74, P<0.001 uncorrected, 67 voxels) (Figure 1b). Findings remained significant for these two SNPs with Bonferroni correction. Analyses were also performed with small volume correction (SVC) for multiple comparisons in the hippocampus that were survived for SNP-3 (P<0.05, corrected), however, not for SNP-2.
