Influence of vascular endothelial growth factor variation on human hippocampus morphology.
paper
Cited
Public
- Authors
- Blumberg, Hilary P; Wang, Fei; Chepenik, Lara G; Kalmar, Jessica H; Edmiston, Elliot Kale; Duman, Ronald S; Gelernter, Joel
- Year
- 2008
- Journal
- Biological psychiatry
- PMID
- 18707678
- DOI
- 10.1016/j.biopsych.2008.07.003
- PMCID
- PMC2649728
BACKGROUND: Morphological abnormalities in hippocampus have been implicated in neuropsychiatric disorders, including depression, schizophrenia, and dementia. Vascular endothelial growth factor (VEGF) has been demonstrated to have neurogenic effects in the hippocampus in rats. However, influence of VEGF variation on hippocampus morphology in humans has yet to be shown. Here, an integrated genetic and neuroimaging approach was used to investigate whether VEGF variation influences hippocampus morphology in humans. METHODS: High-resolution magnetic resonance imaging and voxel-based morphometry were used to identify the influence of genetic variation of VEGFA [rs833068 (SNP-1), rs833070 (SNP-2), rs2146323 (SNP-3) and rs3025020 (SNP-4)] on brain morphology in 47 healthy individuals. RESULTS: Variation in VEGFA SNP-2 and SNP-3 showed significant effects on hippocampus concentration. CONCLUSIONS: The findings suggest that effects of VEGF in hippocampus found in rats extend to humans; further understanding of effects of VEGFA variation might have important implications in identifying individuals more vulnerable to hippocampus pathology as well as those neuropsychiatric populations most likely to benefit from VEGF-mediated interventions.
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| Implications of VEGF gene sequence variations and its expression in recurrent pregnancy loss. | Amin I et al. | — | 2021 | → |
| Neurotrophic factors in bipolar disorders patients with manic episode | Tunçel ÖK et al. | — | 2020 | → |
| Sustained Ultrastructural Changes in Rat Hippocampal Formation After Repeated Electroconvulsive Seizures. | Chen F et al. | — | 2020 | → |
| Elevated serum vascular endothelial growth factor in treatment-resistant schizophrenia treated with electroconvulsive therapy: Positive association with therapeutic effects. | Xiao W et al. | — | 2019 | → |
| Neurocognition and social cognition in remitted first-episode schizophrenia: correlation with VEGF serum levels. | Zhao Y et al. | — | 2019 | → |
| VEGFA GENE variation influences hallucinations and frontotemporal morphology in psychotic disorders: a B-SNIP study. | Lizano P et al. | — | 2018 | → |
| Association of sFlt-1 and worsening psychopathology in relatives at high risk for psychosis: A longitudinal study. | Lizano PL et al. | — | 2017 | → |
| How Electroconvulsive Therapy Works?: Understanding the Neurobiological Mechanisms. | Singh A et al. | — | 2017 | → |
| Angiogenic and immune signatures in plasma of young relatives at familial high-risk for psychosis and first-episode patients: A preliminary study. | Lizano PL et al. | — | 2016 | → |
| Association of serum VEGF levels with prefrontal cortex volume in schizophrenia. | Pillai A et al. | — | 2016 | → |
| Major Depressive Disorder: New Clinical, Neurobiological, and Treatment Perspectives. | Kupfer DJ et al. | — | 2016 | → |
| Association study of VEGFA polymorphisms with schizophrenia in Han Chinese population. | Gao K et al. | — | 2015 | → |
| Endothelin ETA receptor antagonist reverses naloxone-precipitated opioid withdrawal in mice. | Bhalla S et al. | — | 2015 | → |
| Elevated serum levels of FGF-2, NGF and IGF-1 in patients with manic episode of bipolar disorder. | Liu X et al. | — | 2014 | → |
| Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci. | Gelernter J et al. | — | 2014 | → |
| Vascular endothelial growth factor and brain-derived neurotrophic factor in quetiapine treated first-episode psychosis. | Murphy BP et al. | — | 2014 | → |
| Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility. | Cui QT et al. | — | 2013 | → |
| Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage. | Li L et al. | — | 2013 | → |
| Sex differences of gray matter morphology in cortico-limbic-striatal neural system in major depressive disorder. | Kong L et al. | — | 2013 | → |
| Vascular endothelial growth factor gene (VEGFA) polymorphisms may serve as prognostic factors for recurrent depressive disorder development. | Gałecki P et al. | — | 2013 | → |
| VEGF plasma level variations in duloxetine-treated patients with major depression. | Fornaro M et al. | — | 2013 | → |
| Association of nerve growth factor and vascular endothelial growth factor A with psychometric measurements of opiate dependence: results of a pilot study in patients participating in a structured diamorphine maintenance program. | Heberlein A et al. | — | 2012 | → |
| Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. | Blond BN et al. | — | 2012 | → |
| Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide. | Isung J et al. | — | 2012 | → |
| Major depressive disorder: new clinical, neurobiological, and treatment perspectives. | Kupfer DJ et al. | — | 2012 | → |
| Vascular endothelial growth factor (VEGF) and its role in the central nervous system: a new element in the neurotrophic hypothesis of antidepressant drug action. | Nowacka MM et al. | — | 2012 | → |
| Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students. | Katsuura S et al. | — | 2011 | → |
| Effect of the functional VEGFA-583C/T variant on vascular endothelial growth factor levels and the risk of recurrent spontaneous miscarriage. | Al-Khateeb GM et al. | — | 2011 | → |
| Genetic variation in VEGF family genes and breast cancer risk: a report from the Shanghai Breast Cancer Genetics Study. | Beeghly-Fadiel A et al. | — | 2011 | → |
| Psychotic symptoms in the course of sunitinib treatment for advanced renal cell cancer. Two cases. | Schellekens AF et al. | — | 2011 | → |
| The association of genetic variation in CACNA1C with structure and function of a frontotemporal system. | Wang F et al. | — | 2011 | → |
| Vascular Endothelial Growth Factor (VEGF) serum concentration during electroconvulsive therapy (ECT) in treatment resistant depressed patients. | Minelli A et al. | — | 2011 | → |
| Imaging genetics of mood disorders. | Scharinger C et al. | — | 2010 | → |
| Serum levels of vascular endothelial growth factor and its receptors in patients with severe autism. | Emanuele E et al. | — | 2010 | → |
| Antidepressant properties of the 5-HT4 receptor partial agonist, SL65.0155: behavioral and neurochemical studies in rats. | Tamburella A et al. | — | 2009 | → |
| Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans. | Salvadore G et al. | — | 2009 | → |
| Imaging phenotypes of major depressive disorder: genetic correlates. | Savitz JB et al. | — | 2009 | → |