While PRS-CSx can take an arbitrary number of GWAS summary statistics as input, an ancestry-matched LD reference panel is required for each discovery sample, which may be challenging to build for GWAS conducted in admixed populations or in samples with large genomic diversity40. Although we have shown that PRS-CSx is robust to imperfectly matched LD reference panels, future work is needed to better model summary statistics from recently admixed populations41,42.
