The most widely implicated locus was shared among the 5 pairs of psychotic and inflammatory bowel disorders (within 17q12; 17:36809344-38877404, highlighted purple) and contains a GW hit for BD ascribed to candidate gene ERBB2. There were another eight loci that were implicated in four disorder pairs. Among these, one located within 1q32.1 (1:200137649-201589975, highlighted purple) contains GW hits for multiple autoimmune disorders (including celiac disorder, CD, multiple sclerosis, and UC) and is near candidate genes CACNA1S and KIF21B. The full list of loci implicated across multiple disorder pairs is available in Supplementary Table 3. The results of the HESS analysis of putative causal directionality (Table 5) indicated that local genetic correlations were stronger in the loci containing GW hits for SZ (rg ≈ 0.41 ± 0.12) as compared with those containing hits for the paired autoimmune diseases (rg ≈ 0.17 ± 0.13).
