We also sought to examine whether the specific loci might be implicated across multiple psychiatric-immune disorder pairs (Figure 2). An analysis limited to only those surviving BH correction for multiple testing yielded only two loci shared by multiple disease pairs. The first locus (within 3p24.3; 3:21643707-22204244) was identified in correlations of SZ with PBC and with CD; it contained no GWS hits and two genes of unclear consequence ZNF385D and ZNF385D-AS2. The second locus within 8p32.1 (8:11278998-13491775, highlighted brown) was identified in correlations of SZ with PBC and with SLE; this locus contained numerous genes and is adjacent to a GWS hit for SLE associated with candidate gene BLK. When we broadened the scope to examine all loci implicated in nominally significant correlations (uncorrected p < 0.05), we find several that are common to multiple psychiatric-immune disorder pairs (Table 4). The most widely implicated locus was shared among the 5 pairs of psychotic and inflammatory bowel disorders (within 17q12; 17:36809344-38877404, highlighted purple) and contains a GW hit for BD ascribed to candidate gene ERBB2. There were another eight loci that
