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Chunk #20 — Results — Characterization of Loci Contributing to Psychiatric-Immune Genetic Correlations

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Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
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latter. One such locus within 1q21 (1:148361253-151538881, highlighted yellow) contains a SZ association signal localizing near candidate gene APH1A. Another locus within 1q23 (1:159913048-162346721, highlighted yellow) contains a GW hit for SLE, as well as several other autoimmune diseases, associated with candidate gene FCGR2A. Similarly, a locus within 22q11.21 (22:19912358-22357325, highlighted yellow) containing multi-disease association signal is associated with MAPK1 and UBE2L3. Among the loci implicated between SZ and UC, one within 11q13.1 (11:63804569-65898631) harbored GW hits for multiple autoimmune disorders.