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Chunk #19 — Results — Characterization of Loci Contributing to Psychiatric-Immune Genetic Correlations

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Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
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Figure 2) that contained GW hits for both SZ and CD within the present data, and with 4 other autoimmune diseases (immunobase.org); these signals are near autoimmunity candidate genes NFKB1 and MANBA, as well as proposed SZ candidate gene SLC39A8, among others contained within the locus (see Supplementary Table 3). The locus on 10p12.3 (10:18725659-18816236, highlighted green) contains a GW hit for SZ attributed to calcium channel gene CACNB2. Another locus mediating a significantly correlated locus on 12q12 (12:39227169-40816185, highlighted green) contains a GW hit for CD attributed to LRRK2. When examining the loci implicated between SZ and PBC, we observed 3 harboring GW hits for the former and 3 harboring signals for the latter, including loci within 3p24.3 (3:16282442-17891118, highlighted orange) containing PLCL2 and within 11q23.3 (11:117747110-119215476, highlighted orange), containing candidate genes CXCR5, DDX6, and TREH. Among the loci implicated between SZ and SLE, we observed two harboring GW hits for the former and 3 harboring hits for the latter. One such locus within 1q21 (1:148361253-151538881, highlighted yellow) contains a SZ association signal localizing near candidate gene APH1A. Another locus within 1q23 (1:159913048-162346721, highlighted yellow) contains a GW hit for SLE, as well as several other autoimmune diseases, associated