PRS results are shown in Table 3. The PRS based on the CONVERGE major depression GWAS (Converge Consortium, 2015) was positively associated with AD-CrC (PT = 0.005, NSNPS = 2410, beta = 0.151, p = 0.019) and MAXDRINKS (PT = 0.001, NSNPS = 654, beta = 0.200, p = 0.047), supporting shared genetic factors (pleiotropy) between alcohol consumption and major depression. These associations do not, however, survive correction for multiple comparisons (i.e., for the eight PT. threshholds). The major depression PRS was also negatively associated with flushing (PT = 0.001, NSNPS = 654, beta = −0.539, p = 5.00 × 10−3), with the association for flushing remaining significant after multiple-comparison correction.
