Rs1229984 in ADH1B was genotyped directly on both arrays. This marker passed quality control in Sample 2, however, it did not survive quality control in Sample 1. We re-imputed the 2Mb region surrounding rs1229984 in Sample 1 using either AS populations or EAS populations as references, but the imputation quality for rs1229984 did not pass the defined quality threshold (info < 0.8). We thus tested the association between rs1229984 and the alcohol-related traits only in Sample 2; there was an association with AD-CrC at nominal significance (p = 2.72 × 10−5). No association with other traits was observed.
