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Chunk #16 — RESULTS

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Convergence of genome-wide association and candidate gene studies for alcoholism.
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Several commonly reported variants associated with alcoholism are not on the Illumina chip that was used to generate the SAGE dataset. These SNPs include rs671 in ALDH2, rs1229984 in ADH1B, rs4795541 in SLC6A4 and rs3813867 in CYP2E1. Since the A9 allele in SLC6A3 is a VNTR and therefore also not reported in SAGE, we examined two proxy SNPs (Le Strat et al., 2008). Neither of these two SNPs show a significant difference between the cases and controls (p=.8646 for rs27072 and p=.3842 for rs27048).