The JASPAR 2024 release culminates with 2346 TF binding profiles in the CORE collection and 643 in the UNVALIDATED collection (Figure 1 and Supplementary Figure S2). In addition, we generated transcription factor flexible models (TFFMs; hidden Markov-based models capturing dinucleotide dependencies in TF–DNA interactions (33)) using all new CORE PFMs for which ChIP-seq data was available, resulting in 75 new TFFMs (45 for plants, 12 for vertebrates, 11 for insects, and 7 for nematodes). The JASPAR 2024 release compiles 1135 TFFMs (Supplementary Table S4). The web interface to access and visualise all profiles and metadata is accessible at https://jaspar.elixir.no, now hosted by ELIXIR Norway and recognised as a Norwegian bioinformatics service.
