We created a list of prioritized genes using both gene-based tests and colocalization/HEIDI filters. Results from each gene-based test were first restricted to protein coding genes with unique gene identifiers based on the release from GENCODE (v40) for hg19. The following criteria were then used to prioritize genes: (i) a significant (Bonferroni corrected) association from at least two gene-based tests (mBAT-combo, TWAS FUSION, SMR, or PsyOPS), and (ii) evidence of colocalization (COLOC PP4 > 0.8) and/or significant SMR association with HEIDI P > 0.05. Joint/conditional tests of association and significant PWAS associations were used as ancillary approaches to further annotate the prioritized gene list.
