We performed a protein-wide association study (PWAS) using protein expression data from human brain samples. Human brain proteome reference weight data were obtained using the Religious Orders Study and Rush Memory and Aging Project (ROS/MAP) and Banner Sun Health Research Institute (Banner) study. The ROS/MAP proteomes were generated from the dorsolateral prefrontal cortex (DLPFC) of 376 participants of European ancestry and included 1,476 proteins with significant SNP-based heritability (P < 0.01). The Banner PWAS weights were generated from 152 individuals of European ancestry and included 1,147 proteins with significant SNP-based heritability. The PWAS was performed using the TWAS FUSION software20 with LD reference information from the 1000 Genomes Project Phase 396. We corrected for multiple testing using Bonferroni correction.
