On the other hand, the classic fail-safe analysis suggested the association was still strong. For instance, for the allelic analysis at least 1,033 assumed non-significant studies would be required to bring the significant P(Z) value to > 0.05 (814 required for the Asian studies); for the dominant model at least 949 non-significant studies would be required to bring the P value to > 0.05 (716 required for the Asian studies); and for the recessive model at least 235 non-significant studies would bring the P value to > 0.05 (138 required for the Asian studies). These findings, therefore, support that there are strong associations between the SNP and alcoholism as well as alcohol-related diseases. The funnel plots of the Asian studies of AD and alcohol abuse are shown for the allelic analysis, dominant model, and recessive model in Figure 3, and supplementary Figures 2 and 3, respectively. The plots of all the studies of AD and alcohol abuse are shown in supplementary Figures 4–6, indicating the possible changes between the observed and adjusted values of effect size.
