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Chunk #22 — Results — Sensitivity and Retrospective Analyses

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Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.
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According to the sensitivity analyses, no individual study biased the findings to the extent that it could account for the strong observed association. For example, in the Asian populations, the results of AD and alcohol abuse were consistent, regardless of the data set removed, with the allelic P values always between 6×10−34 and 3×10−28. For the dominant model, the results also were consistent, regardless of the data set removed, with the P values always between 8×10−30 and 1×10−24. Supplementary Tables 3 and 4 show the results for the allelic analysis and dominant model of the Asian populations, respectively. The results of all the combined populations are not shown, but are available on request.