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Chunk #16 — Online methods — Assessing Statistical Significance

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Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
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To evaluate the effective number of tests we used the Li and Ji (2005)33 method which performs an initial step of filtering out SNPs with MAF<0.01 (imputation is less reliable for these and power is also limited for most odds ratios). Among the 4,751,148 markers with that MAF there were 1,182,363 effective tests.