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Chunk #32 — Results — 3. Individual SNPs effects on Subjective Responses to Alcohol — 3. A. Visual Analog Drug Effect Questionnaire (VAS)

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GABRA2 markers moderate the subjective effects of alcohol.
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During the alcohol challenge session, subjects with one or two copies of the minor alleles for the following SNPs reported on average significantly lower “Negative” effects (i.e., the sum of “Bad, Dislike and Worst” effects scores) than those homozygous for the common allele after adjusting for time, BAC, genetic ancestry proportion and number of binge drinking episodes (Table 3). rs279858: Negative effects score was lower in carriers of the minor allele, C, than in subjects homozygous for the common allele (F(1, 62) = 8.10, p=0.0060) (Figure 3.A.). rs 279844: Negative effects score was lower in carriers of the minor allele, T, than in subjects homozygous for the common allele (F(1, 62) = 9.22, p=0.0035). rs 279845: Negative effects score was lower in carriers of the minor allele, A, than in subjects homozygous for the common allele (F(1, 61) = 8.70, p=0.0045). rs279826: Negative effects score was lower in carriers of the minor allele, G, than in subjects homozygous for the common allele (F(1, 61) = 8.80, p=0.0043). rs279828: Negative effects score was lower in carriers of the minor allele, C,