day) had higher AUDIT scores [Mean(standard deviation, SD) AUDIT score in non‐smokers = 5.63(4.35), Mean(SD) AUDIT score in smokers = 10.18(5.76)] and 61.6 percent of the subjects with AUDIT ≥ 16 were smokers compared with 9.2 percent in the AUDIT ≤ 1 group. Nevertheless, when the primary analyses involving AUDIT scores or smoking were adjusted for smoking or AUDIT scores, respectively, the association between the outcome variables and the rs2948694 SNP remained significant (P = 0.0489, P = 0.0008, respectively; Table 4). Neither of the investigated GHRL SNPs was associated with AUDIT scores or smoking in any of the genetic models (Gln90Leu: P ≥ 0.12; Leu72Met: P ≥ 0.17; Supporting Information Table S1).
