All studied SNPs had a HWE P‐value > 0.01 and a minor allele frequency of > 5 percent (Table 3). The minor allele of the rs2948694 SNP (G) located in intron 1 of the GHSR gene was associated with increased AUDIT scores (ΔAUDIT = 1.2; P = 0.0204; pc = 0.3672) in a recessive model as well as with smoking in an dominant model (OR = 1.48; P = 0.0002; pc = 0.0036; Table 4). See the Supporting Information for results on the primary outcomes using the other models (Supporting Information Table S1). When a subset of the subjects where selected and classified according to abstainers (AUDIT ≤ 1) and high consumers (AUDIT ≥ 16), the homozygotes for the risk allele had OR = 3.4 to be high consumers (P = 0.0043). Smokers (reporting to smoke > 10 cigarettes per day) had higher AUDIT scores [Mean(standard deviation, SD) AUDIT score in non‐smokers = 5.63(4.35), Mean(SD) AUDIT score in smokers = 10.18(5.76)] and 61.6 percent of the subjects with AUDIT ≥ 16 were smokers compared with 9.2 percent in the AUDIT
