We identified all intra-chromosomal enhancer-promoter pairs (470,315 cases, permissive set of enhancers and unique locations of RefSeq protein-coding gene transcript TSSs +/− 500 bp) within 500 kb, in which the TSS was expressed >1 TPM in at least one sample, and performed Pearson correlation tests between the expression of such pairs: 64% of enhancers had at least one significant association (Benjamini-Hochberg FDR <= 1e-5) within that distance. On average, a TSS was associated with 4.9 enhancers and an enhancer with 2.4 TSSs.
