There was no evidence for genomewide significant loci associated with cannabis dependence symptom counts (Supplemental Table S3; Supplemental Figures S1B and S2B). The most promising association was noted for a cluster of SNPs in chromosome 2 (e.g. rs2287641, p=9E-7). The chromosome 10 SNPs were similarly associated, but not at genomewide significant levels (e.g. rs150525973 P = 1.2E-6).