Lambdas for individual studies and meta-analyses were close to 1.0 (Supplemental Table S1; Figure S1A). Genomewide significant loci did not emerge in any individual study. Meta-analysis of summary statistics from the 5 discovery samples (CATS, COGA-cc, SAGE, COGA-f, OZALC) revealed a cluster of genomewide significant SNPs in a region on chromosome 10 (Table 3 for loci at p-value < 10−6; Supplemental S2A for Manhattan plot; full results available upon request), with genomewide significant loci representing a single signal (Figure 1A for regional association plot (42)). The lowest p-value was associated with rs77300175 (p-value = 1.3E-8; Table 3), with stronger contributions from the 3 case-control cohorts (SAGE, CATS, COGA-cc; Supplemental Table S2) than the family-based cohorts (COGA-f and OZALC+).
