This study used SL and graph theoretic analysis to investigate the topological alterations of EEG functional networks in BD patients. Our main findings were: (1) Global synchronization of the resting-state EEG network in BD patients was significantly reduced in the alpha-band; (2) the de-synchronized connectivity in BD patients was localized, predominantly in fronto-central and centro-parietal connections; (3) the global topological organization in BD patients was altered as indicated by decreased network clustering and increased path length, probably resulting in less efficient network processing; and (4) in BD patients, the changes of network characteristics for the gamma band were associated with depression severity. Taken together, our findings support the hypothesis that the functional topological architecture of resting-state brain network is disrupted in BD, especially in the alpha frequency band.
