with AUDsx (ß = −3.16, p = 0.002) and PTSDsx (ß = −5.19, p = 0.001), suggesting that diminished growth of EEGc was associated with greater AUDsx and PTSDsx. For PFI alpha EEGc (F8-F4--F7-F3), intercept was significantly positively associated with PTSD symptoms in males (ß = 1.05, p < 0.001), and females (ß = 1.69, p < 0.001). Slope of the same coherence pair (F8-F4--F7-F3), was negatively associated with PTSDsx (ß = −2.02, p = 0.0231) in trauma-exposed males, suggesting that higher initial values and diminished growth of PFI alpha EEGc associated with increased PTSDsx. Table 4.Linear growth model results measuring associations between slope and intercept of three frontal alpha EEG coherence pairs and subsequent AUD symptoms in the trauma-exposed subsample of adolescent male and female COGA participantsLeft frontal-central (LFC) EEG coherenceFZ-CZ--F3-C3Right frontal-central (RFC) EEG coherenceFZ-CZ--F4-C4Prefrontal interhemispheric (PFI) EEG coherenceF8-F4--F7-F3MalesFemalesMalesFemalesMalesFemalesBeta (s.e.)pBeta (s.e.)pBeta (s.e.)pBeta (s.e.)pBeta (s.e.)pBeta (s.e.)pAssociations with AUD and PTSD symptomsIntercept on AUD symptoms0.08 (0.45)0.8620.53 (0.12)<0.0014.10 (0.19)<0.001−0.58 (0.66)0.3770.41 (0.60)0.4940.53 (1.10)0.633Slope on AUD symptoms−0.91 (0.77)0.237−0.79 (0.77)0.305−1.55 (1.26)0.218−3.16 (1.03)0.002−1.39 (0.83)0.094−0.22 (0.58)0.700Intercept on PTSD symptoms0.28 (0.15)0.0662.65 (0.12)<0.0012.47 (0.09)<0.0010.15 (0.18)0.4191.05 (0.13)<0.0011.69 (0.08)<0.001Slope on PTSD symptoms0.01 (0.48)0.992−0.48 (0.94)0.612−0.22 (0.56)0.699−5.19 (1.52)0.001−2.02 (0.89)0.023−0.82 (0.55)0.137Correlation between AUD and PTSD symptoms0.01 (0.01)0.3120.01 (0.01)0.5520.00 (0.01)0.8630.01 (0.01)0.494−0.00 (0.01)0.8870.00 (0.01)0.718Observations408–459–408–459–408–459–AIC3034.34–3950.75–3061.07–3934.99–2900.58–3497.02–BIC3198.81–4120.04–3225.54–4104.28–3065.04–3666.31–H0 log-likelihood−1476.17–−1934.37–−1489.537–−1926.49−1409.29–−1707.51–H1 maximum
