One reviewer has reported that another software "genetic power calculator" (GPC) [1] can be used to estimate statistical power in GWA studies with quantitative traits, with some simple adjustments. A major difference between GPC and GWAPower is that GPC is based on a comprehensive mixed model approach [12], making it amenable for use in various experimental designs. GWAPower takes advantage of the fact that most GWA study designs are reasonably simple, and much simpler models such as ANOVA or regression models are often adequate. In such cases, the approximations of estimating distribution parameters are not necessary.
