Although GWAPower is developed for GWA studies, it can be used for general genetic studies if researchers wish to use heritability as the parameter for genetic effect size. However, this approach should be used with caution. Some complicating factors are not considered such as population stratification, various interactions among genetic variants, and environmental factors. Furthermore, Bonferroni correction for multiple tests is known to be over-conservative. Therefore, for complicated designs with multiple confounding factors, researchers are encouraged to consult a statistical geneticist.
