Adolescent animals exposed to intermittent EtOH and evaluated postmortem showed no effects on FA but reduced axial diffusivity (hippocampus, cortex, and cerebellum), reduced radial diffusivity (hippocampus and cortex), and reduced MD (cerebellum and corpus callosum) in several brain regions (Vetreno et al. 2016). Adult rats exposed to a single dose of EtOH showed a slight and transient reduction, relative to unaffected rats, in ADC in brainstem (Kong et al. 2013), frontal lobe, hippocampus, thalamus, and cerebellum (Liu et al. 2014). These findings were interpreted as reflecting the development of cytotoxic brain edema, as histological analysis showed cell swelling and narrowed extracellular spacing (Kong et al. 2013).
