Whereas chronic exposure to vaporized EtOH did not result in detectable effects on FA or MD, binge EtOH exposure resulted in transient decreases in FA and transient increases in MD (Pfefferbaum et al. 2015). Together, these results suggest that DTI can detect acute and subchronic effects on the brain, but that chronic exposure to EtOH can result in brain adaptations such that effects on FA and MD are no longer discernable.
