The parameters used to construct the networks described above were such that the vast majority of genes share edges with at least half of the remaining network. Subsets of genes shared edges with nearly all network members, and were more important to the network based on measurements of connectivity and centrality. These network hub genes could be major regulators of the transcriptional response to acute ethanol and more generally, may represent key points of vulnerability in underlying signaling pathways responding to ethanol. We therefore identified hub genes by ranking network members based on their degree of connectivity and betweenness centrality. (Table S3).
